Methods for the Development of Cationic Nanocapsules for the Topical Administration of Tretinoin: A Box-Behnken Approach, In Vitro Assessment, and Ex Vivo Epidermal Deposition Research
DOI:
https://doi.org/10.46243/jst.2025.v10.i6.pp48-67Keywords:
Design-Expert, TTN, cationic acrylic, N-terminal thicknessAbstract
An exciting new direction in topical administration is the use of cationic nanocapsules. To improve the photostability, user compliance, and pharmacodynamic effectiveness of tretinoin (TTN), we built on a new formulation that relies on cationic nanocapsules. The nanoprecipitation process was used to create TTN nanocapsules in order to accomplish this. A Box-Behnken design was used with the help of Design-Expert software to statistically optimize the formulation variables. The cationic acrylic polymer weight (X1), oil volume (X2), and total transdermal N-terminal thickness (X3) were the three independent variables that were examined. As for the dependent variables, we chose particle size and encapsulation efficiency percentage (EE%).
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