Formulation and Development of Topical Flurbiprofen Emulgel by using Xanthan Gum

Pallavi M. Chaudhari; Jyoti Bala

doi:10.46243/jstj.2020.v5.i2.264

Authors

Pallavi M. Chaudhari
Jyoti Bala

DOI:

https://doi.org/10.46243/jstj.2020.v5.i2.264

Keywords:

Topical emulgel, flurbiprofen, NSAID, xanthan gum, liquid paraffin and eucalyptus oil

Abstract

Flurbiprofen is non-steroidal anti-inflammatory drug used for the treatment of

rheumatoid arthritis as an autoimmune disease that causes chronic inflammation of the joints. Flurbiprofen is a potent inhibitor of platelets aggregation, which reduce pain, swelling and joint stiffness. The objective of this study was to formulate and evaluate topical flurbiprofen emulgel for the delivery of hydrophobic drugs to systemic circulation. In present work flurbiprofen emulgel was prepared by using liquid paraffin (oil), eucalyptus oil (penetration enhancer) and xanthan gum used as gelling agent. All formulations evaluated for homogeneity, pH, extrudability, spreadability, viscosity, drug content and drug release. In-vitro drug release of emulgel was evaluated by using diffusion cell containing cellophane membrane with phosphate buffer pH 7.4 as the receptor medium. The formulations were optimized by the three factors and two levels Box-Behnken design by using Design-Expert software (version 12). Spreadability of F6 formulation was observed (3.4 cm in diameter) which was more than other formulations. Viscosity of F16 formulation was 3067 cps. Percentage Drug content of F14 (98.61%) has shown more drug content as compared other formulations. In-vitro diffusion studies, the formulations F5, F6, F13, F14 and F16 has shown more than 80 % of drug release for 8 hrs.

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