Illumination of Gold Nanoparticles for Tumor Angiogenesis
DOI:
https://doi.org/10.46243/jst.2021.v6.i2.pp87-104Keywords:
Nanoparticle, Occular Imaging, Radio-sensitive, Angiogenesis, Peptides, IlluminationAbstract
This paper reports on the evolution of tumor-specific gold nanoparticles (AuNPs) as theranostic tools intended for target accumulation and the detection of tumor angiogenesis via ocular image (OI) before diagnosis is started, before initiation with an external X-ray radiation source. The AuNPs were decorated with a near-infrared dye, and RGD peptides as the tumor targeting vector for αvβ3-integrin, which is overexpressed in tissue with high tumor angiogenesis. The AuNPs were examined in an ocular image setting in vitro and in vivo exhibiting approving diagnostic properties with regards to tumor cell accumulation, bio-distribution, and clearance. Further- more, the therapeutic features of the AuNPs were evaluated in vitro on pUC19 DNA and on A431 cells concerning acute and long-term toxicity, indicating that these AuNPs could be useful as radio-sensitizers in therapeutic concepts in the future.
References
Mayo, R.L.; Robinson, F.R.S. Auger and secondary X-ray electrons from gold. Royal Soc. Pub. 1939, 173, 192–200
Zhang, X.D.; Wu, D.; Shen, X.; Chen, J.; Sun, Y.M.; Liu, P.X.; Liang, X.J. Size-dependent radiosensitization of PEG-coated goldnanoparticles for cancer radiation therapy. Biomaterials 2012, 33, 6408–6419, doi:10.1016/j.biomaterials.2012.05.047
Hainfeld, J.F.; Slatkin, D.N.; Smilowitz, H.M. The use of gold nanoparticles to enhance radiotherapy in mice. Phys. Med. Biol.2004, 49, N309–N315, doi:10.1088/0031-9155/49/18/n03
Säterborg, N.E. The distribution of 198Au injected intravenously as a colloid and in solution. ActaRadiol. Ther. Phys. Biol. 1973,12, 509–528
Khan, M.K.; Minc, L.D.; Nigavekar, S.S.; Kariapper, M.S.T.; Nair, B.M.; Schipper, M.; Cook, A.C.; Lesniak, W.G.; Balogh, L.P.Fabrication of {198Au0} radioactive composite nanodevices and their use for nano-brachytherapy. Nanomed.Nanotechnol. Biol.Med. 2008, 4, 57–69
Chakravarty, R.; Chakraborty, S.; Guleria, A.; Kumar, C.; Kunwar, A.; Nair, K.V.V.; Sarma, H.D.; Dash, A. Clinical scalesynthesis of intrinsically radiolabeled and cyclic RGD peptide functionalized 198Au nanoparticles for targeted cancer therapy.Nucl. Med. Biol. 2019, 72–73, 1–10, doi:10.1016/j.nucmedbio.2019.05.005
Makrigiorgos, G.; Adelstein, S.J.; Kassis, A.I. Auger electron emitters: Insights gained from in vitro experiments. Radiat. Environ.Biophys. 1990, 29, 75–91
Hauck, T.S.; Ghazani, A.A.; Chan, W.C. Assessing the effect of surface chemistry on gold nanorod uptake, toxicity, and geneexpression in mammalian cells. Small 2008, 4, 153–159, doi:10.1002/smll.200700217
Pan, Y.; Neuss, S.; Leifert, A.; Fischler, M.; Wen, F.; Simon, U.; Schmid, G.; Brandau, W.; Jahnen-Dechent, W. Sizedependentcytotoxicity of gold nanoparticles. Small 2007, 3, 1941–1949, doi:10.1002/smll.200700378
Mironava, T.; Hadjiargyrou, M.; Simon, M.; Jurukovski, V.; Rafailovich, M.H. Gold nanoparticles cellular toxicity and recovery:Effect of size, concentration and exposure time. Nanotoxicology 2010, 4, 120–137, doi:10.3109/17435390903471463
Cai, Q.Y.; Yu, P.; Besch-Williford, C.; Smith, C.J.; Sieckman, G.L.; Hoffman, T.J.; Ma, L. Near-infrared fluorescence imaging ofgastrin releasing peptide receptor targeting in prostate cancer lymph node metastases. Prostate 2013, 73, 842–854, doi:10.1002/pros.22630
Chen, H.; Wan, S.; Zhu, F.; Wang, C.; Cui, S.; Du, C.; Ma, Y.; Gu, Y. A fast tumor-targeting near-infrared fluorescent probe basedon bombesin analog for in vivo tumor imaging. Contrast Media Mol. Imaging 2014, 9, 122–134, doi:10.1002/cmmi.1545
Ma, L.; Yu, P.; Veerendra, B.; Rold, T.L.; Retzloff, L.; Prasanphanich, A.; Sieckman, G.; Hoffman, T.J.; Volkert, W.A.; Smith, C.J.In vitro and in vivo evaluation of alexafluor 680-bombesin[7–14]NH2 peptide conjugate, a high-affinity fluorescent probe withhigh selectivity for the gastrinreleasing peptide receptor. Mol. Imaging 2005, 16, 171–180
Herdt, A.R.; Drawz, S.M.; Kang, Y.; Taton, T.A. DNA dissociation and degradation at gold nanoparticle surfaces. Colloids Surf.,B 2006, 51, 130–139, doi:10.1016/j.colsurfb.2006.06.006
Bhatt, N.; Huang, P.J.; Dave, N.; Liu, J. Dissociation and degradation of thiol-modified DNA on gold nanoparticles in aqueousand organic solvents. Langmuir ACS J. Surf. Colloids 2011, 27, 6132–6137, doi:10.1021/la200241d
Igaz, N.; Szoke, K.; Kovacs, D.; Buhala, A.; Varga, Z.; Belteky, P.; Razga, Z.; Tiszlavicz, L.; Vizler, C.; Hideghety, K.; et al.Synergistic radiosensitization by gold nanoparticles and the histone deacetylase inhibitor SAHA in 2D and 3D cancer cellcultures. Nanomaterials 2020, 10, doi:10.3390/nano10010158
Kassis, A.I. Molecular and cellular radiobiological effects of Auger emitting radionuclides. Radiat. Prot. Dosim. 2011, 143, 241–247, doi:10.1093/rpd/ncq385
Chanda, N.; Kan, P.; Watkinson, L.D.; Shukla, R.; Zambre, A.; Carmack, T.L.; Engelbrecht, H.; Lever, J.R.; Katti, K.; Fent, G.M.;et al. Radioactive gold nanoparticles in cancer therapy: Therapeutic efficacy studies of GA-198AuNP nanoconstruct in prostatetumor-bearing mice. Nanomedicine : nanotechnology, biology, and medicine 2010, 6, 201–209, doi:10.1016/j.nano.2009.11.001
Pretze, M.; Hien, A.; Roscher, M.; Richter, K.; Rädle, M.; Wängler, C.; Wängler, B. Efficient modification of GRPR-specific goldnanoparticles for fluorescence imaging of prostate carcinoma. J. Labelled Compd. Radiopharm. 2017, 60, S601, doi:10.1002/jlcr.3508
Hien, A.; Pretze, M.; Braun, F.; Schäfer, E.; Kümmel, T.; Roscher, M.; Schock-Kusch, D.; Waldeck, J.; Müller, B.; Wängler, C.; etal. Non-contact recognition of fluorescently labeled objects in deep tissue via optimized optical arrangement. PLoS ONE 2018,13, e0208236, doi:10.1371/journal.pone.0208236
Zhu, J.; Chin, J.; Wängler, C.; Wängler, B.; Lennox, R.B.; Schirrmacher, R. Rapid 18F-labeling and loading of PEGylated goldnanoparticles for in vivo applications. Bioconjug. Chem. 2014, 25, 1143–1150, doi:10.1021/bc5001593
Zhao, Y.; Sultan, D.; Detering, L.; Cho, S.; Sun, G.; Pierce, R.; Wooley, K.L.; Liu, Y. Copper-64-alloyed gold nanoparticles forcancer imaging: improved radiolabel stability and diagnostic accuracy. Angew. Chem. Int. Ed. 2014, 53, 156–159,doi:10.1002/anie.201308494
Pretze, M.; van der Meulen, N.P.; Wängler, C.; Schibli, R.; Wängler, B. Targeted 64Cu-labeled gold nanoparticles for dual imagingwith positron emission tomography and optical imaging. J. Labelled Comp. Radiopharm. 2019, 62, 471–482, doi:10.1002/jlcr.3736
Jiménez-Mancilla, N.; Ferro-Flores, G.; Santos-Cuevas, C.; Ocampo-García, B.; Luna-Gutiérrez, M.; Azorín-Vega, E.; Isaac-Olivé,K.; Camacho-López, M.; Torres-García, E. Multifunctional targeted therapy system based on 99mTc/177Lu-labeled goldnanoparticles-Tat(49-57)-Lys3-bombesin internalized in nuclei of prostate cancer cells. J. Labelled Compd. Radiopharm. 2013, 56,663–671, doi:10.1002/jlcr.3087
Kim, M.S.; Lee, E.J.; Kim, J.W.; Chung, U.S.; Koh, W.G.; Keum, K.C.; Koom, W.S. Gold nanoparticles enhance anti-tumor effectof radiotherapy to hypoxic tumor. Radiat. Oncol. J. 2016, 34, 230–238, doi:10.3857/roj.2016.01788
Black, K.C.L.; Wang, Y.; Luehmann, H.P.; Cai, X.; Xing, W.; Pang, B.; Zhao, Y.; Cutler, C.S.; Wang, L.V.; Liu, Y.; et al. Radioactive198Au-Doped Nanostructures with Different Shapes for In Vivo Analyses of Their Biodistribution, Tumor Uptake, andIntratumoral Distribution. ACS Nano 2014, 8, 4385–4394, doi:10.1021/nn406258m
Cui, S.; Yin, D.; Chen, Y.; Di, Y.; Chen, H.; Ma, Y.; Achilefu, S.; Gu, Y. In vivo targeted deep-tissue photodynamic therapy basedon near-infrared light triggered upconversionnanoconstruct. ACS Nano 2013, 7, 676–688, doi:10.1021/nn304872n
Shukla, R.; Chanda, N.; Zambre, A.; Upendran, A.; Katti, K.; Kulkarni, R.R.; Nune, S.K.; Casteel, S.W.; Smith, C.J.; Vimal, J.; etal. Laminin receptor specific therapeutic gold nanoparticles (198AuNP-EGCg) show efficacy in treating prostate cancer. Proc.Natl. Acad. Sci. USA 2012, 109, 12426–12431, doi:10.1073/pnas.1121174109
Maeda, H.; Fang, J.; Inutsuka, T.; Kitamoto, Y. Vascular permeability enhancement in solid tumor: various factors, mechanismsinvolved and its implications. Int. Immunopharmacol. 2003, 3, 319–328, doi:10.1016/s1567-5769(02)00271-0
Zarschler, K.; Rocks, L.; Licciardello, N.; Boselli, L.; Polo, E.; Garcia, K.P.; De Cola, L.; Stephan, H.; Dawson, K.A. Ultrasmallinorganic nanoparticles: State-of-the-art and perspectives for biomedical applications. Nanomed.Nanotechnol. Biol. Med. 2016, 12,1663–1701, doi:10.1016/j.nano.2016.02.019
Frens, G. Controlled Nucleation for the Regulation of the Particle Size in Monodisperse Gold Suspensions. Nat. Phys. Sci. 1973,241, 20–22, doi:10.1038/physci241020a0
Brust, M.; Walker, M.; Bethell, D.; Schiffrin, D.J.; Whyman, R. Synthesis of Thiol-derivatised Gold Nanoparticles in a TwophaseLiquid-Liquid System. J. Chem. Soc. Chem. Commun. 1994, 801–802, doi:10.1039/C39940000801
Turkevich, J. Colloidal Gold. Part I—Historical and preparative aspects, morphology and structure. Gold Bull. 1985, 18, 86–91,doi:10.1007/BF03214690
