Formulation, Development and Evaluation of Topiramate Loaded Niosomes for the Treatment of Epilepsy
DOI:
https://doi.org/10.46243/jst.2020.v5.i5.pp119-129Keywords:
Niosomes, Tween 80, Labrafi, Ether injection methodAbstract
Topiramate (TPM) is an anti-epileptic drug used in the treatment of epilepsy and seizures. The study was designed with three aims. First, to enhance the solubility and bioavailability of BCS class III drug TPM; second, to ease administration of the formulation to the epileptic patient, during an attack, and third, to decrease the dose of drug for enduring treatment. Formulation of TPM niosomes was optimized by changing the concentration of Tween, Labrafil and cholesterol using response surface design. Further the TPM niosomes were prepared by using ether injection method. The formulation was then evaluated for vesicle size, entrapment efficiency and in-vitro drug release study. FTIR and DSC studies were performed for pure drug and optimized batch. The vesicle size of the optimized batch was found to be 0. 35 nm. The %entrapment efficiency and %drug release of optimized batch was found to be 94.64% and 92.027% respectively. From the present study it can be concluded that the developed niosomes of TPM has shown great potential in treatment of epilepsy.
References
Rampal RAJERA, Kalpana NAGPAL, Shailendra Kumar SINGH, and Dina Nath Mishra. Niosomes: A Controlled and Novel Drug Delivery System. Biological & Pharmaceutical Bulletin. 2011; 4(7) 945—953
Namrata Mishra, Vinamrata Srivastava, Anu Kaushik, Vivek Chauhan, Gunjan Srivastava. Formulation and in-vitro evaluation of Niosomes of Aceclofenac. Journal of Scientific and Innovative Research. 2014; 3(3): 337-341
Surendra Agrawal, Vaishali Londhe, Ram Gaud. Niosomes: Layered Delivery System For Drug Targeting. International Journal of Scientific Research. 2014; 3(1): 2277–8179
Devender Sharma, Aashiya Aara E. Ali, Jayshree R. Aate. Niosomes as Novel Drug Delivery System: Review Article. Magazne Pharmatutor Orgnization. 2018; 6(3): 58-65
Veldurthi Ravalika, Abbaraju Krishna Sailaja. Formulation and evaluation of etoricoxib niosomes by thin film hydration technique and ether injection method. Nano Biomed Eng 2017. 9(3): 242-248
Shilpa P. Chaudhari and Vibhavari M. Chatur. Development of Valproic Acid Niosomal in situ Nasal Gel Formulation for Epilepsy. Indian Journal of Pharmaceutical Education and Research. 2013; 47(3): 31-41
Elaine C. Moreland, David A. Griesemer & Kenton R. Holden. Topiramate for intractable childhood epilepsy. British Epilepsy Association1997; 38(8) :193-194
Herrero AI, Del Olmoa N, Gonzalez-Escaladab JR, Solis JM. Two new actions of topiramate: inhibition of depolarizing GABAA-mediated responses and activation of a potassium conductance”, Neuropharmacology (2002); 42: 210–220
Professor of Paediatric Neurology and Head of Neurology Unit, Pediatric Hospital A Meyer and University of Florence. Topiramate in the Treatment of Epilepsy–A Review. European Neurological Disease. 2006; 40-44
Philip N. Patsalos. The Mechanism of Action of Topiramate. Rev. Contemp. Pharmacother. 1999; l0:147-153
P. Ravi Prakash, M. S. Jayasheela, R. Raghavenra Prasad, P. Chandini, A. Praveena, K. Sree Lakshmi and P. Ramesh. Candesertan niosomesformulation and evaluation using Span 60 as non-ionic surafactant. Journal of Chemical and Pharmaceutical Research. 201; 57(7): 940-949
Shilpa P. Chaudhari and Vibhavari M. Chatur. Development of valproic acid niosomal in situ nasal Gel formulation for epilepsy. Indian Journal of Pharmaceutical Education and Research. 2013; 47(3): 31-41
Gyati Shilakari Asthana, Parveen Kumar Sharma, and Abhay Asthana. In Vitro and In Vivo Evaluation of Niosomal Formulation for Controlled Delivery of Clarithromycin. https://www.hindawi.com/journals/scientifica/2016/6492953/
Ahmed M.S. Ahmed1, Mamdouh M. Ghourab, Shedid G. She Did, and Mona K. E. Qushawy. Optimization of piroxicam niosomes using central composite design. International Journal of Pharmacy and Pharmaceutical Sciences. 2013; 5(3): 29-236
Nidhi Shah, Mahesh K Gupta, Neetesh K Jain. Formulation, optimization and characterization of naproxen noisome. Current Research in Biological and Pharmaceutical Sciences. 2015; 4(5): 10-15
Gannu P. Kumar, PogakuRajeshwarrao. Nonionic surfactant vesicular systems for effective drug delivery—an overview.ActaPharmaceuticaSinica B 2011; 1(4): 208-219
Tamizharasi S, Dubey A, Rathi V, Rathi JC. Development and characterization of niosomal drug delivery of gliclazid. Journal Young Pharmaceuticals 2009; 1(3):205-209
Md. Ullah H, Bhuyian, Dr. Rashid H, Md. Moshin, and Tahera KT: An overview: stability study of pharmaceutical products and shelf life prediction. European J. Biomed. Pharm. Sci. 2015; 2(6): 30-40 129 | Page
Published
How to Cite
Issue
Section
