Sphingosomes: A Novel Lipoidal Vesicular Drug Delivery System
DOI:
https://doi.org/10.46243/jst.2020.v5.i4.pp261-267Keywords:
Targeted drug delivery, Vesicular drug delivery, Sphingosomes, Sphingolipids, CholesterolAbstract
Vesicular drug delivery system has various advantages thereby improving therapeutic efficacy and by sustaining and controlling action of drugs. Liposomes, sphingosomes, ethosomes, cubosomes, pharmacasomes, niosomes, transferosomes are the newly developed vesicular drug delivery system. This review article mainly deals with the sphingosomal drug delivery system. Sphingosomes are vesicular drug delivery systems in which an aqueous volume is enclosed with sphingolipid bilayer membranes. Sphingosomes has an enhanced area of interest because of their applicability in improving the in vivo delivery of various chemotherapeutic agents, biological macromolecules and diagnostics. Sphingosome has major advantages over other vesicular drug delivery systems like high stability, more in vivo circulation time, high tumor loading efficacy in case of cancer therapy as compared to liposomes, niosomes etc. Sphingosomes are clinically used vesicular delivery system for chemotherapeutic agent, biological macromolecule and diagnostics. This review concluded that sphingosome represents a promising vesicular drug delivery system for a range of possible therapeutic applications.
References
Mohd. Gayoor K han. Topic-The novel drug delivery system. World journal of pharmacy and pharmaceutical sciences, 2017; 6(7): 477-487
Nidhi Mishra1*, Prerna Pant1, Ankit Porwal1, JuhiJaiswal. Targeted Drug Delivery: A Review. American Journal of PharmTech Research, 2016; 6(1): 1-24
M. Gupta and V. Sharma, “Targeted drug delivery system: A review,” Research Journal of Chemical Sciences, 2011; 1: 134-138
Robinson JR, Lee VHL. Controlled drug delivery: Fundamentals and Applications. second edition., Informa healthcare; 20: 56-57
Molema G, Meijer DKF. Drug Targeting Organ-Specific Strategies. Wiley-VCH Verlag GmbH, 2001: 157–170
Shah Adarsh A et al. Organelle Specific Targeted Drug Delivery- A Review. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2011; 2(3): 895-912
Shailza Singh et al. Molecular drug targets and structure based drug design: A holistic approach. Bioinformation, 2006; 1(8): 314-320
Stuti Gupta, Ravindra Pal Singh, PriyankaLokwani, SudhirYadav, Shivjee KG. Vesicular system as targeted drug delivery system: An overview. International journal of pharmacy and technology, 2011; 3: 987-1021
MayankGangwar, Ragini Singh, Goel RK, Gopalnath. Recent Advances in various emerging vesicular system: An Overview. Asian Pacific Journal of Tropical Biomedicine, 2012:1-4
Jain NK. Controlled and Novel Drug Delivery. First edition. CBS Publishers and Distributors, New Delhi, 2001
Ravi Kumar, Shivjee Kumar, Shyam Shankar Jha, Amit Kumar Jha. Vesicular System-Carrier for Drug Delivery. Der Pharm acia Sinica, 2011; 2(4):192-202
SwarnalathaSaraf, Paliwal S, ShailendraSaraf. Sphingosomes A novel approach to vesicular drug delivery. International Journal of current scientific research, 2011; 1(1):63-68
Kumar D, Sharma D, Singh G, Singh M, Rathore M. S, Lipoidal soft hybrid biocarriers of supramolecular construction for drug delivery, International Scholar of research network pharm, 2012: 1-14
S. Lankalapalli and M. Damuluri, “Sphingosomes: applications in targeted drug delivery,” International Journal of Pharmaceutical, Chemical and Biological Sciences, 2012; 2(4): 507–516
K. Ashok, A. Rajendra Kumar, S. Nama, B. Brahmaiah, P. K. Desu, and C. B. Rao, “Sphingosomes: a novel vesicular drug delivery system,” International Journal of Pharmaceutical Research and Bio-Science, 2013; 2(2): 305–312
SrinivasLankalapalli and MadhupriyaDamuluri. Sphingosomes: applications in targeted drug delivery. International journal of pharmaceutical, chemical and biological sciences, 2012; 2(4): 507-516
Shailza S. Molecular drug targets and structure based design: A holistic approach, bioinformation, 2006; 1(8): 314-320
P. Divakar, D. Kumar, C. Praveen, C. Sowmya, and C. Suryaprakash Reddy, “Formulation and in vitro evaluation of liposomes containing metformin hydrochloride,” International Journal of Research in Pharmaceutical and Biomedical Sciences, 2013; 4(2): 479–
Sphingosomes: A Novel Lipoidal Vesicular Drug Delivery System 267 | Page
Saraf S, Gupta D, Kaur C.D. Sphingosomes a novel approach to vesicular drug delivery, International journal of current scient ific research, 2011; 1(2): 63-68
Edward A.D. A comprehensive classification system for lipids, Journal of lipid research, 2005; 46: 851-854
Tikshdeep C, Sonia A, Bharat P, Abhishek C. Liposome drug delivery: A review, International journal of pharmaceutical and chemical sciences, 1(3), 2012, 754-764
Stuti G, Ravindra P.S, Priyanka L, Sudhir Y, Shivjee G.K. Vesicular system as targeted drug delivery system: An overview, International journal of pharmacy and technology, 3(2), 2011, 987-1000. 25
Papahadjo P.D, Vail W.J, Ann N.Y, Acad Sci. 308, 1978, 259. 26
Hamilton R. L, Guo L.S.S. Liposome Technology, CRC Press, Florida, 1, 1984, 37
SwarnlataSaraf, S. Paliwal, ShailendraSaraf. Sphingosomes a novel appoach to vesicular drug delivery. International Journal o f Current Scientific Research, 2011; 1(2): 63-68
Vishakha, Ethosome: A novel vesicular drug delivery, World journal of pharmaceutical research, 2015; 4(4): 1199-1210
Abhishek C, Ethosomes: A novel approach towards transdermal drug delivery, 2012; 1(2): 565
Pooja V, Ethosomes: A novel drug carrier for transdermal drug delivery. IJPRSBS, 2012; 1(6): 1-9
Dileep P. Formulation and evaluation of itraconazoleethosomal gel, 2015;5(2): 85-87
Dave V, Dhirondra K. Ethosome for enhanced transdermal drug delivery of aceclofenac, International journal of drug delivery, 2015;2:81-83
Rodriquez et al. Vincristine sulphate liposomes injection ( Marqibo) in heavily pretreated patients with refractory aggressive non hodgkin lymphoma: report of the pivotal phase 2 study. Cancer. 2009;115(15):3475-82
Sphingosomes Moist LS 9871–for optimal skin purifying with moisturizing and skin barrier strengthe ning benefits. SpecialChem.2009
Mathew B et al. Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs. Faseb J. 2011;25(10):3388-400
Baumruker T, Prieschl EE. Sphingolipids and the regulation of the immune response. Seminimmunol. 2002;14(1):57-63
