Supplementation of Vitamin D improves Insulin Resistance and Oxidative Stress in PCOS women. A Comprehensive Review
DOI:
https://doi.org/10.46243/jst.2021.v6.i04.pp216-226Keywords:
Vitamin D,, PCOS, Insulin Resistance, Oxidative stress, C-reactive proteinAbstract
The aim of the present review was to evaluate the effect of vitamin D (VD) supplementation (alone or co-supplementation) on insulin resistance and oxidative stress in VD deficient polycystic ovary syndrome (PCOS) subjects. Using PubMed, Google Scholar and Web of Science, we searched for publications in the last 10 years regarding the role of VD in PCOS students. It was found that the prevalence of VD deficiency was higher in PCOS subjects in comparison to control. We compared the effects of supplementation of VD in PCOS patients on insulin resistance (IR) value and oxidative stress markers (MDA). It was found that VD as a co-supplement could significantly decrease fasting glucose concentrations and the HOMAIR value. Further VD supplementation in patients with PCOS resulted in a significant improvement in high sensitivity C-reactive protein (hs-CRP), total antioxidant capacity (TAC), and malondialdehyde (MDA
References
Ming-Wei Lin and Meng-Hsing Wu. The role of vitamin D in Polycystic ovary syndrome, Indian J Med Res. 2015 Sep, 142(3): 238–240
de Groot PC, Dekkers OM, Romijn JA, Dieben SW & Helmerhorst FM. PCOS, coronary heart disease, stroke and the influence of obesity: a systematic review and meta-analysis. Human Reproduction Update. 2011, 17: 495–500
Diamanti-Kandarakis E & Dunaif A. Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocrine Reviews. 2012, 33: 981–1030
Wild RA, Rizzo M, Clifton S & Carmina E. Lipid levels in polycystic ovary syndrome: systematic review and meta-analysis. Fertility and Sterility. 2011, 95: 1073–1079
Raja-Khan, N. Shah, J. Stetter, C.M. Lott, M.E. Kunselman, A.R. Dodson, W.C. Legro. R.S. High-dosevitamin Dsupplementation and measures of insulin sensitivity in polycystic ovary syndrome: A randomized, controlledpilottrial. Fertil. Steril. 2014, 101: 1740–1746
Maktabi M., Chamani M., Asemi Z. The effects of vitamin D supplementation on metabolic status of patients with polycystic ovary syndrome: A randomized, doubleblind, placebo-controlled trial. Horm. Metab. Res. 2017, 49: 493–498
Gupta T., Rawat M., Gupta N., Arora S. Study of effect of vitaminDsupplementation onthe clinical, hormonal and metabolicprofile of the PCOSWomen. J. Obstet.Gynaecol. India. 2017, 67: 349–335
Jamilian M., Foroozanfard F., Rahmani E., Talebi M., Bahmani F., Asemi Z. Effect of two different doses of vitamin D supplementation on metabolic profiles of insulinresistant patients with polycystic ovary syndrome. Nutrients 2017, 24: 1280
Abootorabi M., Ayremlou P., Behroozi-Lak T., Nourisaeidlou S. The effect of vitamin D supplementation on insulin resistance, visceral fat and adiponectin in vitamin D deficient women with polycystic ovary syndrome: A randomized controlled trial. Gynecol. Endocrinol. 2018, 34: 489–494
Karadag C, Yoldemir T et al., effects of Vitamin D supplementation on insulin sensitivity and androgen levels in vitamin D-deficient polycystic ovary syndrome patients. J obstetrics and Gynae. Res.2018, 44 (2), 270-277
Karamali M., Ashrafi M., Razavi M., Jamilian M., Kashanian M., Akbari M., Asemi Z. The effects of calcium, vitamins D and K co-supplementation on markers of insulin metabolism and lipid profiles in vitamin D-deficient women with polycystic ovary syndrome. Exp. Clin. Endocrinol. Diabetes. 2017, 125: 316–321
Trummer C, Schwez V, Kollmann M, et al. Effects of vitamin D supplementation on metabolic and endocrine parameters in PCOS: a randomized-controlled trial. Eur J Nutr 2019, 58: 2019-28
Mishra P, Samanta L. Oxidative stress and heart failure in altered thyroid states. The scientific world journal. 2012. 2012, 1-17
N. I. Khan, L. Naz, and G. Yasmeen. Obesity: an independent risk factor for systemic oxidative stress. Pakistan Journal of Pharmaceutical Sciences. 2006, 19(1): 62–65
M. Murri, M. Luque-ramírez, M. Insenser, M. Ojeda-ojeda, and H. F. Escobarmorreale. Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis. Human Reproduction Update. 2013,19(3): 268–288
Bloch-Damti and N. Bashan. Proposed mechanisms for the induction of insulin resistance by oxidative stress, Antioxidants & Redox Signaling. 2005, 7(11-12): 1553–1567
Sunil J. Wimalawansa. Vitamin D deficiency: effects on oxidative stress, epigenetics, gene regulation and ageing, Biology(Basel), 2019, 8(2): 30
Sung JY, Chung W, Kim AJ, et al. Calcitriol treatment increases serum levels of the soluble receptor of advanced glycation end products in hemodialysis patients with secondary hyperparathyroidism. Tohoku J Exp Med. 2013, 230(1): 59–66
Liefaard MC, Ligthart S, et al. Vitamin D and C-Reactive Protein: A Mendelian Randomization Study. Plos one. 2015, 10(7): e0131740
Foroozanfard F, Jamilian M, Bahmani F, et al. Calcium plus vitamin D supplementation influences biomarkers of inflammation and oxidative stress in overweight and vitaminD-deficient women with polycystic ovary syndrome: a randomized doubleblind placebo-controlled clinical trial. Clin Endocrinol (Oxf). 2015, 83: 888-94
Razavi M, Jamillian M, Karamali M, et al. The Effects of Vitamin D-K-Calcium Co-Supplementation on Endocrine, Inflammation, and Oxidative Stress Biomarkers in VitaminD-Deficient Women with Polycystic Ovary Syndrome:A Randomized, Double-Blind,PlaceboControlled Trial. Horm Metab Res 2016, 48: 446-51
Jamilian M, Foroozanfard F, Rahmani E, et al. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome. Nutrients. 2017, 9: 1280. Ovary Syndrome. Nutrients 2019, 11: 188
Fatemi F, Mohammadzadeh A, Sadeghi MR, et al. Role of vitamin E and D3 supplementation in Intra-Cytoplasmic Sperm Injection outcomes of women with polycystic ovarian syndrome: A double blinded randomized placebocontrolled trial. Clin Nutr ESPEN. 2017, 18: 23-30
Nasri K, Akrami S, Rahimi M, et al. The effects of vitamin D and evening primrose oil co-supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D- P age 223 | 11 Published by: Longman Publishers www.jst.org.in deficient women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Endocr Res. 2018, 43: 1-10
Maktabi M, Jamilian M, Asemi Z. Magnesium-ZincCalcium-Vitamin D Cosupplementation Improves Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, PlaceboControlled Trial. Biol Trace Elem Res. 2018, 182: 21-8
Ostadmohammadi V, Jamilian M, Bahani F, et al. Vitamin D and probiotic cosupplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome. J Ovarian Res, 2019, 12: 5
Published
How to Cite
Issue
Section
