Synthesis, Characterization and Antimicrobial Activity of A Chalcone Derivative
DOI:
https://doi.org/10.46243/jst.2020.v5.i4.pp335-343Keywords:
Claisen-Schmidt condensation, Chalcone, antimicrobial activityAbstract
An area of great interest in recent years has been chalcones. Chalcones are the important component of many natural sources and have variety of biological activities. Chalcones which are also known as α,βunsaturated ketones is an significant class of organic compounds and reported to possess a wide spectrum of biological activities such as antibacterial, antifungal, anticancer, anti-inflammatory etc. Abundant research papers have been published and chalcones continue to show promise for new drug investigations. The derivative of chalcones were prepared using Claisen–Schmidt condensation scheme. The structure of the synthesized was confirmed by UV and IR. The compound was also tested for their antimicrobial activity.
References
Kostanecki and Tambor S. V. J. Chem Ber., 32, 1921 1899
Yerra, K.R., S. Fang and Y.M. Tzeng,. Synthesis of 2 oxygenated chalcones. Bioorg. Med. Chem., 12, 2679-2686 2004
Rupe H and Wasserzug D, J. Chem Ber., 34, 3527 1901
Hermes S.A, Chem Ber., 70, 9642 2h 1969
Breslow D.S and Houser C.R, Chem Ber., 62, 2385 1940
Kazauki K, Hitayama K, Yokomor S and Soki T, Chem Abstr., 85, 591 1976
Z. Nowakowska, Eur. J. Med. Chem. 42, 125 2007 CrossRef Google Scholar
S. Lopez et al., Bioorg. Med. Chem. 9, 1999 2001 CrossRef Google Scholar
P. Boeck et al., Arch Pharmacy 338, 87 2005 CrossRef Google Scholar
H.N. Elsohly, A.S. Joshi, A.C. Nimrod, L.A. Walker, A.M. Clark, Planta Medica 67, 87 2001 CrossRef Google Scholar
N. Yayli et al., J. Photochem.Photobiol. A 169, 229 2005 CrossRef Google Scholar
M.V.B. Reddy et al., Bioorg. Med. Chem. 16, 7358 2008 CrossRef Google Scholar
G. Saydam et al., Lukemia Research 27, 57 2003 CrossRef Google Scholar
M. Cabrera et al., Bioorg. Med. Chem. 15, 356 2007 CrossRef Google Scholar
C. Nakamura et al., Bioorg. Med. Chem. 10, 699 2002 CrossRef Google Scholar
A. Modzelewska, C. Pettit, G. Achanta, N.E. Davidson, P. Huang, S.R. Khan, Bioorg. Med. Chem. 14, 3491 2006 CrossRef Google Scholar
L. Troeberg et al., Mol. Med. 6, 660 2000 Google Scholar
V.J. Ram, A.X. Saxena, S. Srivastava, S. Chandra, Bioorg. Med. Chem. Lett. 10, 2159 2000 CrossRef Google Scholar
Perez, C., Pauli, M. and Bazerque, P.(1990). An antibiotic assay by the agar-well diffusion method. Acta Biol. Med. Exp. 15: 113- 115
Erdemogßlu, N., Ku¨ Peli, E., Yes, E. and Ilada, R. (2003). Antiinflammatory and antinociceptive activity assessment of plants used as remedy in Turkish folk medicine. J. Ethnopharmacol.89: 123
Bagamboula, C.F., Uyttendaele, M. and Debevere, J. (2004). Inhibitory effect of thyme and basil essential oils, carvacro l, thymol, estragol, linalool and p-cymene towards Shigella sonnei and S. flexneri. Food Microbiol. 21: 33-42




