A Review of Investigational Treatments for Covid-19 - Zinc Supplementary
DOI:
https://doi.org/10.46243/jst.2021.v6.i3.pp17-20Keywords:
: COVID-19, SARS-CoV-2, Immune system, Zinc supplementAbstract
Zinc (Zn) is an investigational agent against Coronavirus disease 2019 (COVID-19) and has known protective and medicinal function for other infections. Due to the quick increase and vast number of pretentious individuals worldwide, cost-effective, globally available, and safe options with minimal side effects and simple application are extremely warranted. Zn deficiency is associated with lower survival among older patients with pneumonia and predisposes to other viral infections. Zn supplement has an efficacious against COVID-19 and to improve normal immune cell function, in particular in elderly patients. Zinc may decrease the activity of the angiotensin converting enzyme 2, the receptor for SARS-CoV-2. Zinc T-cell modulation may down regulate the cytokine storm associated with severe COVID-19. Therefore, it may be suggested that Zn supplementation may be of potential support for treatment of COVID-19
References
Kumar A, Kubota Y, Chernov M, Kasuya H. Potential role of zinc supplementation in prophylaxis and treatment of COVID-19. Medical Hypotheses. 2020; 144: 109848
World Health Organization. Updated WHO advice for international traffic in relation to the outbreak of the novel coronavirus 2019 nCoV. 2020. Available at: https://www.who.int/ith/2020 2401outbreakofpneumoniacausedbynewcoronavirus/en/. 2020
Robert BS and Rebecca R. Zinc: An Essential Micronutrient. Am Fam Physician. 2009; 79(9): 768
Zumla A, Chan JF, Azhar EI et al. Coronaviruses—drug discovery and therapeutic options. Nat Rev Drug Discov. 2016; 15(5):327–347
Abdulhamid I, Beck FW, Millard S, Chen X, Prasad A. Effect of zinc supplementation on respiratory tract infections in children with cystic fibrosis. Pediatr Pulmonol. 2008; 43: 281–287
Hemila H, Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage. JRSM Open. 2017; 8: 2054270417694291
Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother. 1984; 25: 20–24
Philip MC, Tania A, Christopher P, Harish R, Simon J, Joseph R. Hydroxychloroquine and azithromycin plus zinc vs hydroxychloroquine and azithromycin alone: outcomes in hospitalized COVID-19 patients. Journal of Medical Microbiology. 2020
Zhang L and Liu Y. Potential interventions for novel coronavirus in China: A systematic review. J Med Virol. 2020; 92: 479-490
Hemila H. Zinc lozenges may shorten the duration of colds: a systematic review. Open Respir Med J 2011; 5: 51–58
SKALNY et al. Zinc and respiratory tract infections: Perspectives for COVID-19 (Review). International Journal of Molecular Medicine. 2020
Inga W, Benjamin R and Lothar R. The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis Frontiers in Immunology. www.frontiersin.org. 2020; 11: 1712
Amit K, Yuichi K, Mikhail C, Hidetoshi K. Potential role of zinc supplementation in prophylaxis and treatment of COVID-19. Medical Hypotheses. 2020; 144: 109848
Ademola Adetokunbo Oyagbemi., et.al., Potential health benefits of zinc supplementation for the management of COVID ‐19 pandemic. J Food Biochem. 2021; 00: 13604
Hemila H and Chalker E. The effectiveness of high dose zinc acetate lozenges on various common cold symptoms: a meta-analysis. BMC Family Practice. 2015. 16: 24
Petrus EJ, Lawson KA, Bucci LR, et al. Randomized, double-masked, placebo-controlled clinical study of the effec tiveness of zinc acetate lozenges on common cold symptoms in allergy-tested subjects. Current therapeutic research, 1998; 59
SHORT COMMUNICATION Carlucci et al. Zinc sulfate in combination with a Zinc ionophore may improve outcomes in hospitalized COVID-19 patients. Journal of Medical Microbiology. 2020; 69:1228–1234
Eby GA. Zinc lozenges: cold cure or candy? Solution chemistry determinations. Biosci Rep. 2004; 24: 23–39
Eby GA. Zinc lozenges as cure for the common cold–a review and hypothesis. Med Hypotheses. 2010; 74: 482–492
Al-Nakib W, Higgins PG, Barrow I, et al. Prophylaxis and treatment of rhinovirus colds with zinc gluconate lozenges. J Antimicrob A Review of Investigational Treatments for Covid-19-Zinc Supplementary 20 | Page Chemother. 1987; 20: 893–901
Smith AP, Tyrrell DA, Al-Nakib W, et al. Effects of zinc gluconate and nedocromil sodium on performance deficits produced by the common cold. J Psychopharmacol 1991; 5: 251–254
Godfrey JC, Sloane BC, Smith DS, et al. Zinc gluconate and the common cold: a controlled clinical study. J Int Med Res. 1992; 20: 234–246
Mossad SB, Macknin ML, Medendorp SV, et al. Zinc gluconate lozenges for treating the common cold. A randomized, double-blind, placebo-controlled study. Ann Intern Med. 1996; 125: 81–88
Eby GA, Davis DR and Halcomb WW. Reduction in duration of common cold by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother. 1984; 25: 20–24
Xue J, Moyer A, Peng B, Wu J, Hannafon BN et al. Chloroquine is a Zinc ionophore. PLoS One. 2014; 9




